InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTSS

Summary

InnateDB Protein

IDBP-102191.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSS

Protein Name

cathepsin S

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357981

InnateDB Gene

IDBG-102189 (CTSS)

Protein Structure

UniProt Annotation

Function

Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.

Subcellular Localization

Lysosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	3 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001968	fibronectin binding
GO:0004197	cysteine-type endopeptidase activity
GO:0005518	collagen binding
GO:0008233	peptidase activity
GO:0008234	cysteine-type peptidase activity
GO:0043236	laminin binding
GO:0043394	proteoglycan binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002250	adaptive immune response
GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002480	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
GO:0006508	proteolysis
GO:0006955	immune response
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0030574	collagen catabolic process
GO:0034769	basement membrane disassembly
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0045087	innate immune response (InnateDB)
GO:0050729	positive regulation of inflammatory response
GO:0051603	proteolysis involved in cellular protein catabolic process
GO:0097067	cellular response to thyroid hormone stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005764	lysosome
GO:0016020	membrane
GO:0036021	endolysosome lumen
GO:0043202	lysosomal lumen
GO:0043231	intracellular membrane-bounded organelle