Version 5.4
Homo sapiens Protein: PRUNE
Summary
InnateDB Protein IDBP-102250.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRUNE
Protein Name prune homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000271620
InnateDB Gene IDBG-102248 (PRUNE)
Protein Structure
UniProt Annotation
Function Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269PubMed:10602478, ECO:0000269PubMed:11687967, ECO:0000269PubMed:14998490, ECO:0000269PubMed:16428445, ECO:0000269PubMed:17906697}.
Subcellular Localization Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
Disease Associations
Tissue Specificity Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269PubMed:10602478, ECO:0000269PubMed:11687967, ECO:0000269PubMed:15671547}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004427 inorganic diphosphatase activity
GO:0005515 protein binding
GO:0016462 pyrophosphatase activity
GO:0030145 manganese ion binding
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005925 focal adhesion
Protein Structure and Domains
PDB ID
InterPro IPR001667 DDH domain
IPR004097 DHHA2 domain
PFAM PF01368
PF02833
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q86TP1
PhosphoSite PhosphoSite-Q86TP1
TrEMBL Q5SZF2
UniProt Splice Variant
Entrez Gene 58497
UniGene Hs.743351
RefSeq NP_067045
HUGO HGNC:13420
OMIM
CCDS CCDS977
HPRD 15188
IMGT
EMBL AF051907 AF123538 AF123539 AK027875 AK294154 AK298273 AK315120 AK316537 AL122054 AL590133 BC014886 BC025304 BC063481 CH471121 U67085
GenPept AAC95290 AAF04914 AAH14886 AAH25304 AAH63481 AAK00592 AAK00593 BAB55423 BAG37575 BAG57478 BAG60534 BAH14908 CAH56396 CAI13338 CAI13341 CAI13342 CAI13343 EAW53486 EAW53488 EAW53489

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca