InnateDB Protein
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IDBP-102260.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRUNE
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Protein Name
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prune homolog (Drosophila)
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357931
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InnateDB Gene
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IDBG-102248 (PRUNE)
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Protein Structure
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Function |
Phosphodiesterase (PDE) that has higher activity toward cAMP than cGMP, as substrate. Plays a role in cell proliferation, is able to induce cell motility and acts as a negative regulator of NME1. {ECO:0000269PubMed:10602478, ECO:0000269PubMed:11687967, ECO:0000269PubMed:14998490, ECO:0000269PubMed:16428445, ECO:0000269PubMed:17906697}.
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Subcellular Localization |
Cytoplasm. Nucleus. Cell junction, focal adhesion. Note=In some transfected cells a nuclear staining is also observed.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Seems to be overexpressed in aggressive sarcoma subtypes, such as leiomyosarcomas and malignant fibrous histiocytomas (MFH) as well as in the less malignant liposarcomas. {ECO:0000269PubMed:10602478, ECO:0000269PubMed:11687967, ECO:0000269PubMed:15671547}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
3
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q86TP1
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PhosphoSite |
PhosphoSite-Q86TP1
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58497
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UniGene |
Hs.743351
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RefSeq |
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HUGO |
HGNC:13420
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OMIM |
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CCDS |
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HPRD |
15188
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IMGT |
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EMBL |
AF051907
AF123538
AF123539
AK027875
AK294154
AK298273
AK315120
AL122054
AL590133
BC014886
BC025304
BC063481
CH471121
U67085
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GenPept |
AAC95290
AAF04914
AAH14886
AAH25304
AAH63481
AAK00592
AAK00593
BAB55423
BAG37575
BAG57478
BAG60534
CAH56396
CAI13338
CAI13341
CAI13342
CAI13343
EAW53486
EAW53488
EAW53489
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