Version 5.4
Homo sapiens Protein: MLLT11
Summary
InnateDB Protein IDBP-102278.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MLLT11
Protein Name myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
Synonyms AF1Q;
Species Homo sapiens
Ensembl Protein ENSP00000357917
InnateDB Gene IDBG-244926 (MLLT11)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations Note=A chromosomal aberration involving MLLT11 is found in acute leukemias. Translocation t(1;11)(q21;q23) with KMT2A/MLL1.
Tissue Specificity Highly expressed in thymus and all leukemic cell lines. {ECO:0000269PubMed:7833468}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 5 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0043065 positive regulation of apoptotic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051901 positive regulation of mitochondrial depolarization
GO:0090200 positive regulation of release of cytochrome c from mitochondria
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097193 intrinsic apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13015
PhosphoSite PhosphoSite-Q13015
TrEMBL Q6FGF7
UniProt Splice Variant
Entrez Gene 10962
UniGene Hs.75823
RefSeq NP_006809
HUGO HGNC:16997
OMIM 604684
CCDS CCDS982
HPRD 05251
IMGT
EMBL AK056089 AL590133 BC006471 BC008445 BC009624 BC019253 BC021703 BC022448 BT006799 CH471121 CR456879 CR542150 U16954
GenPept AAA70088 AAH06471 AAH08445 AAH09624 AAH19253 AAH21703 AAH22448 AAP35445 BAG51620 CAG33160 CAG46947 CAI13350 EAW53476

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca