InnateDB Protein
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IDBP-102349.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PI4KB
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Protein Name
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phosphatidylinositol 4-kinase, catalytic, beta
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Synonyms
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NPIK; PI4K-BETA; PI4K92; PI4KBETA; PI4KIIIBETA; PIK4CB;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357869
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InnateDB Gene
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IDBG-102347 (PI4KB)
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Protein Structure
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Function |
Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). {ECO:0000250}.
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Subcellular Localization |
Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex.
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Disease Associations |
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Tissue Specificity |
Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. {ECO:0000269PubMed:9020160, ECO:0000269PubMed:9405935, ECO:0000269PubMed:9405938}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
17
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
1
[view]
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0004430
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1-phosphatidylinositol 4-kinase activity
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GO:0005515
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protein binding
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GO:0005524
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ATP binding
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GO:0016772
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transferase activity, transferring phosphorus-containing groups
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GO:0016773
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phosphotransferase activity, alcohol group as acceptor
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000403
Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR011009
Protein kinase-like domain
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PFAM |
PF00454
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PRINTS |
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PIRSF |
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SMART |
SM00146
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UBF8
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PhosphoSite |
PhosphoSite-Q9UBF8
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TrEMBL |
F8W860
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UniProt Splice Variant |
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Entrez Gene |
5298
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UniGene |
Hs.607923
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RefSeq |
NP_002642
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HUGO |
HGNC:8984
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OMIM |
602758
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CCDS |
CCDS993
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HPRD |
11805
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IMGT |
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EMBL |
AB005910
AJ011121
AJ011122
AJ011123
AK294606
AL391069
BC000029
BC040300
CH471121
U81802
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GenPept |
AAC51156
AAH00029
AAH40300
BAA21661
BAG57793
CAA09495
CAA09496
CAH70324
CAH70325
CAH70326
EAW53449
EAW53450
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