InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PI4KB

Summary

InnateDB Protein

IDBP-102357.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PI4KB

Protein Name

phosphatidylinositol 4-kinase, catalytic, beta

Synonyms

NPIK; PI4K-BETA; PI4K92; PI4KBETA; PI4KIIIBETA; PIK4CB;

Species

Homo sapiens

Ensembl Protein

ENSP00000357866

InnateDB Gene

IDBG-102347 (PI4KB)

Protein Structure

UniProt Annotation

Function

Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol- 1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity). {ECO:0000250}.

Subcellular Localization

Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-bisphosphate (PIP2) on the Golgi complex.

Disease Associations

Tissue Specificity

Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly expressed in liver. {ECO:0000269PubMed:9020160, ECO:0000269PubMed:9405935, ECO:0000269PubMed:9405938}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.

Experimentally validated
Total	21 [view]
Protein-Protein	17 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004430	1-phosphatidylinositol 4-kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor

Biological Process

GO:0006644	phospholipid metabolic process
GO:0006661	phosphatidylinositol biosynthetic process
GO:0006898	receptor-mediated endocytosis
GO:0007165	signal transduction
GO:0044281	small molecule metabolic process
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005741	mitochondrial outer membrane
GO:0005768	endosome
GO:0005829	cytosol
GO:0030867	rough endoplasmic reticulum membrane
GO:0048471	perinuclear region of cytoplasm