InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: E4F1

Summary

InnateDB Protein

IDBP-10237.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

E4F1

Protein Name

E4F transcription factor 1

Synonyms

E4F;

Species

Homo sapiens

Ensembl Protein

ENSP00000301727

InnateDB Gene

IDBG-10235 (E4F1)

Protein Structure

UniProt Annotation

Function

May function as a transcriptional repressor. May also function as a ubiquitin ligase mediating ubiquitination of chromatin-associated TP53. Functions in cell survival and proliferation through control of the cell cycle. Functions in the p53 and pRB tumor suppressor pathways and regulates the cyclin CCNA2 transcription.Identified as a cellular target of the adenoviral oncoprotein E1A, it is required for both transcriptional activation and repression of viral genes.

Subcellular Localization

Nucleus, nucleoplasm. Cytoplasm. Note=A small fraction is detected in the cytoplasm. Excluded from the nucleolus where it is targeted upon CDKN2A overexpression. Localizes to the mitotic spindle during embryogenesis (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. {ECO:0000269PubMed:9530632}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding
GO:0001227	RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0035497	cAMP response element binding
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006260	DNA replication
GO:0006351	transcription, DNA-templated
GO:0007067	mitotic nuclear division
GO:0008283	cell proliferation
GO:0009794	regulation of mitotic cell cycle, embryonic
GO:0010564	regulation of cell cycle process
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0040008	regulation of growth
GO:0071850	mitotic cell cycle arrest