InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: THEM4

Summary

InnateDB Protein

IDBP-102451.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THEM4

Protein Name

thioesterase superfamily member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357804

InnateDB Gene

IDBG-102449 (THEM4)

Protein Structure

UniProt Annotation

Function

Has acyl-CoA thioesterase activity towards medium and long-chain (C14 to C18) fatty acyl-CoA substrates, and probably plays an role in mitochondrial fatty acid metabolism. Plays a role in the apoptotic process, possibly via its regulation of AKT1 activity. According to PubMed:11598301, inhibits AKT1 phosphorylation and activity. According to PubMed:17615157, enhances AKT1 activity by favoring its phosphorylation and translocation to plasma membrane. {ECO:0000269PubMed:11598301, ECO:0000269PubMed:17615157, ECO:0000269PubMed:19168129, ECO:0000269PubMed:19421406, ECO:0000269PubMed:19453107, ECO:0000269PubMed:22871024}.

Subcellular Localization

Cell membrane. Cell projection, ruffle membrane. Cytoplasm. Mitochondrion. Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion intermembrane space. Note=Released from the mitochondria into the cytosol in response to apoptotic stimuli.

Disease Associations

Tissue Specificity

Expressed predominantly in skeletal muscle, testis, uterus, brain and kidney. Down-regulated in glioblastoma or glioma compared to non-neoplastic brain due to promoter hypermethylation. {ECO:0000269PubMed:11598301, ECO:0000269PubMed:15026474}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	2 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016290	palmitoyl-CoA hydrolase activity

Biological Process

GO:0006631	fatty acid metabolic process
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0008286	insulin receptor signaling pathway
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0043491	protein kinase B signaling
GO:0045087	innate immune response
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:1902108	regulation of mitochondrial membrane permeability involved in apoptotic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005758	mitochondrial intermembrane space
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0032587	ruffle membrane