Version 5.4
Homo sapiens Protein: S100A11
Summary
InnateDB Protein IDBP-102461.4
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol S100A11
Protein Name S100 calcium binding protein A11
Synonyms HEL-S-43; MLN70; S100C;
Species Homo sapiens
Ensembl Protein ENSP00000271638
InnateDB Gene IDBG-102459 (S100A11)
Protein Structure
UniProt Annotation
Function Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269PubMed:18618420}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:18618420}. Nucleus {ECO:0000269PubMed:18618420}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 18 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0044548 S100 protein binding
GO:0048306 calcium-dependent protein binding
Biological Process
GO:0007165 signal transduction
GO:0008156 negative regulation of DNA replication
GO:0008285 negative regulation of cell proliferation
Cellular Component
GO:0001726 ruffle
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002048 EF-hand domain
IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
PFAM PF00036
PF13202
PF13405
PF01023
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P31949
PhosphoSite PhosphoSite-P31949
TrEMBL V9HWH9
UniProt Splice Variant
Entrez Gene 6282
UniGene Hs.593414
RefSeq NP_005611
HUGO HGNC:10488
OMIM 603114
CCDS CCDS1009
HPRD 04385
IMGT
EMBL AL591893 BC001410 BC014354 BT009912 CH471121 D38583 D49355 D50374 EU794659 X80201
GenPept AAH01410 AAH14354 AAP88914 ACJ13713 BAA07597 BAA08354 BAA23325 CAA56492 CAH72895 EAW53392

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca