Version 5.4
Homo sapiens Protein: DNASE1L2
Summary
InnateDB Protein IDBP-10248.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNASE1L2
Protein Name deoxyribonuclease I-like 2
Synonyms DNAS1L2;
Species Homo sapiens
Ensembl Protein ENSP00000316938
InnateDB Gene IDBG-10244 (DNASE1L2)
Protein Structure
UniProt Annotation
Function Divalent cation-dependent acid DNA endonuclease involved in the breakdown of the nucleus during corneocyte formation of epidermal keratinocytes. May play an immune role by eliminating harmful DNA released into the extracellular environment by damaged epidermal cells. {ECO:0000269PubMed:16902420}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:16902420}. Secreted {ECO:0000305}.
Disease Associations
Tissue Specificity Preferentially expressed in the skin and up- regulated during keratinocytes differentiation. Highly abundant (at protein level) in the stratum granulosum. {ECO:0000269PubMed:16902420}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0004536 deoxyribonuclease activity
GO:0005509 calcium ion binding
GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters
Biological Process
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006259 DNA metabolic process
GO:0006308 DNA catabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
IPR016202 Deoxyribonuclease I
PFAM PF03372
PF14529
PRINTS PR00130
PIRSF PIRSF000988
SMART SM00476
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q92874
PhosphoSite PhosphoSite-Q92874
TrEMBL
UniProt Splice Variant
Entrez Gene 1775
UniGene Hs.103503
RefSeq NP_001365
HUGO HGNC:2958
OMIM 602622
CCDS CCDS42105
HPRD 04018
IMGT
EMBL AC009065 AK098028 AY298957 AY298958 BC035205 BC063710 CH471112 U62647
GenPept AAB63981 AAH35205 AAH63710 AAQ73759 AAQ73760 AAQ73761 BAG53566 EAW85526 EAW85527 EAW85528 EAW85529

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca