Version 5.4
Homo sapiens Protein: SMCP
Summary
InnateDB Protein IDBP-102575.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMCP
Protein Name sperm mitochondria-associated cysteine-rich protein
Synonyms HSMCSGEN1; MCS; MCSP;
Species Homo sapiens
Ensembl Protein ENSP00000357754
InnateDB Gene IDBG-102573 (SMCP)
Protein Structure
UniProt Annotation
Function Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm. Mitochondrion membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Note=Becomes associated with the spermatid mitochondrion capsule at step 16 of spermatogenesis. {ECO:0000250}.
Disease Associations
Tissue Specificity Testis. Is selectively expressed in the spermatids of seminiferous tubules. {ECO:0000269PubMed:8833144}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0007341 penetration of zona pellucida
GO:0030317 sperm motility
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0031966 mitochondrial membrane
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P49901
PhosphoSite PhosphoSite-
TrEMBL Q5T7P5
UniProt Splice Variant
Entrez Gene 4184
UniGene
RefSeq NP_109588
HUGO HGNC:6962
OMIM 601148
CCDS CCDS1029
HPRD 03093
IMGT
EMBL AK312020 BC014593 BC016744 CH471121 X89960 X89961
GenPept AAH14593 AAH16744 BAG34957 CAA62000 CAD56487 EAW53361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca