Version 5.4
Homo sapiens Protein: IVL
Summary
InnateDB Protein IDBP-102578.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IVL
Protein Name involucrin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357753
InnateDB Gene IDBG-102576 (IVL)
Protein Structure
UniProt Annotation
Function Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia.
Subcellular Localization Cytoplasm. Note=Constituent of the scaffolding of the cornified envelope.
Disease Associations
Tissue Specificity Keratinocytes of epidermis and other stratified squamous epithelia.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0030674 protein binding, bridging
Biological Process
GO:0010224 response to UV-B
GO:0018149 peptide cross-linking
GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
GO:0030216 keratinocyte differentiation
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR000354 Involucrin repeat
IPR019571 Involucrin, N-terminal
PFAM PF00904
PF10583
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P07476
PhosphoSite PhosphoSite-P07476
TrEMBL J3KPN6
UniProt Splice Variant
Entrez Gene 3713
UniGene Hs.630324
RefSeq NP_005538
HUGO HGNC:6187
OMIM 147360
CCDS CCDS1030
HPRD 00931
IMGT
EMBL AL162596 BC046391 M13903
GenPept AAA59186 AAH46391 CAI19553

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca