Version 5.4
Homo sapiens Protein: SPRR4
Summary
InnateDB Protein IDBP-102581.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRR4
Protein Name small proline-rich protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000332163
InnateDB Gene IDBG-102579 (SPRR4)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. Involved in UV-induced cornification.
Subcellular Localization Cytoplasm. Cytoplasm, cell cortex. Note=Translocates to the cell periphery of keratinocytes and is integrated into both rigid and fragile cornified envelopes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0018149 peptide cross-linking
GO:0031424 keratinization
Cellular Component
GO:0005737 cytoplasm
GO:0005938 cell cortex
Protein Structure and Domains
PDB ID
InterPro IPR003302 Cornifin (SPRR1)
PFAM PF02389
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96PI1
PhosphoSite PhosphoSite-Q96PI1
TrEMBL
UniProt Splice Variant
Entrez Gene 163778
UniGene Hs.433629
RefSeq NP_775103
HUGO HGNC:23173
OMIM
CCDS CCDS1031
HPRD 18101
IMGT
EMBL AF335109 AL356867 BC069445 BC069549 BC112170 BC112172
GenPept AAH69445 AAH69549 AAI12171 AAI12173 AAK96400 CAI19800

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca