Version 5.4
Homo sapiens Protein: SPRR2D
Summary
InnateDB Protein IDBP-102605.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SPRR2D
Protein Name small proline-rich protein 2D
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357745
InnateDB Gene IDBG-102595 (SPRR2D)
Protein Structure
UniProt Annotation
Function Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane.
Subcellular Localization Cytoplasm.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0008544 epidermis development
GO:0031424 keratinization
Cellular Component
GO:0001533 cornified envelope
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P22532
PhosphoSite PhosphoSite-P22532
TrEMBL
UniProt Splice Variant
Entrez Gene 6703
UniGene
RefSeq
HUGO HGNC:11264
OMIM
CCDS CCDS30864
HPRD 01650
IMGT
EMBL AF333954 AK291317 AL356867 BC120938 CH471121 M21302
GenPept AAA36640 AAI20939 AAK70941 BAF84006 CAI19806 EAW53348 EAW53349 EAW53350

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca