InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100A7

Summary

InnateDB Protein

IDBP-102678.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A7

Protein Name

S100 calcium binding protein A7

Synonyms

PSOR1; S100A7c;

Species

Homo sapiens

Ensembl Protein

ENSP00000357712

InnateDB Gene

IDBG-102676 (S100A7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:8618345}. Secreted {ECO:0000269PubMed:8618345}. Note=Secreted by a non- classical secretory pathway.

Disease Associations

Tissue Specificity

Fetal ear, skin, and tongue and human cell lines. Highly up-regulated in psoriatic epidermis. Also highly expressed in the urine of bladder squamous cell carcinoma (SCC) bearing patients. {ECO:0000269PubMed:8618345}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	24 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0000302	response to reactive oxygen species
GO:0001525	angiogenesis
GO:0008544	epidermis development
GO:0010820	positive regulation of T cell chemotaxis
GO:0030216	keratinocyte differentiation
GO:0032496	response to lipopolysaccharide
GO:0045087	innate immune response
GO:0050829	defense response to Gram-negative bacterium
GO:0051238	sequestering of metal ion
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071624	positive regulation of granulocyte chemotaxis
GO:0090026	positive regulation of monocyte chemotaxis

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005829	cytosol
GO:0005925	focal adhesion
GO:0070062	extracellular vesicular exosome