InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: S100A3

Summary

InnateDB Protein

IDBP-102704.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100A3

Protein Name

S100 calcium binding protein A3

Synonyms

S100E;

Species

Homo sapiens

Ensembl Protein

ENSP00000357702

InnateDB Gene

IDBG-102702 (S100A3)

Protein Structure

UniProt Annotation

Function

Binds both calcium and zinc. May be involved in calcium- dependent cuticle cell differentiation, hair shaft and hair cuticular barrier formation. {ECO:0000269PubMed:18083705}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:18083705}.

Disease Associations

Tissue Specificity

Skin specific, specifically expressed at the inner endocuticle of hair fibers. {ECO:0000269PubMed:12470658}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0008270	zinc ion binding

Biological Process

Cellular Component

GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR013787 S100/CaBP-9k-type, calcium binding, subdomain

PFAM

PF01023

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33764

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

6274

UniGene

RefSeq

NP_002951

HUGO

HGNC:10493

OMIM

176992

CCDS

CCDS1043

HPRD

01507

IMGT

EMBL

BC012893 BT006955 BX470102 CH471121 CR542163 CR542185 Z18948 Z18950

GenPept

AAH12893 AAP35601 CAA79471 CAA79473 CAG46960 CAG46982 CAI14755 EAW53306 EAW53307