Version 5.4
Homo sapiens Protein: ILF2
Summary
InnateDB Protein IDBP-102764.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ILF2
Protein Name interleukin enhancer binding factor 2, 45kDa
Synonyms NF45; PRO3063;
Species Homo sapiens
Ensembl Protein ENSP00000357673
InnateDB Gene IDBG-102762 (ILF2)
Protein Structure
UniProt Annotation
Function Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. {ECO:0000269PubMed:10574923, ECO:0000269PubMed:11739746, ECO:0000269PubMed:21123651, ECO:0000269PubMed:9442054}.
Subcellular Localization Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 225 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 225 [view]
Protein-Protein 223 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
Biological Process
GO:0006955 immune response
GO:0008152 metabolic process
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006116 2-5-oligoadenylate synthetase, N-terminal
IPR006561 DZF domain
PFAM PF07528
PRINTS
PIRSF
SMART SM00572
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-Q12905
TrEMBL X6R6Z1
UniProt Splice Variant
Entrez Gene 3608
UniGene Hs.75117
RefSeq
HUGO HGNC:6037
OMIM 603181
CCDS
HPRD 04419
IMGT
EMBL AL592150 AL713889
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca