InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ILF2

Summary

InnateDB Protein

IDBP-102766.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ILF2

Protein Name

interleukin enhancer binding factor 2, 45kDa

Synonyms

NF45; PRO3063;

Species

Homo sapiens

Ensembl Protein

ENSP00000355011

InnateDB Gene

IDBG-102762 (ILF2)

Protein Structure

UniProt Annotation

Function

Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. {ECO:0000269PubMed:10574923, ECO:0000269PubMed:11739746, ECO:0000269PubMed:21123651, ECO:0000269PubMed:9442054}.

Subcellular Localization

Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 225 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	225 [view]
Protein-Protein	223 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016740	transferase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006955	immune response
GO:0008152	metabolic process
GO:0045893	positive regulation of transcription, DNA-templated