InnateDB Protein
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IDBP-102768.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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ILF2
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Protein Name
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interleukin enhancer binding factor 2, 45kDa
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Synonyms
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NF45; PRO3063;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357670
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InnateDB Gene
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IDBG-102762 (ILF2)
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Protein Structure
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Function |
Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA. Essential for the efficient reshuttling of ILF3 (isoform 1 and isoform 2) into the nucleus. {ECO:0000269PubMed:10574923, ECO:0000269PubMed:11739746, ECO:0000269PubMed:21123651, ECO:0000269PubMed:9442054}.
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Subcellular Localization |
Nucleus, nucleolus. Cytoplasm. Nucleus. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 225 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
225
[view]
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Protein-Protein |
223
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
1
[view]
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR006116
2-5-oligoadenylate synthetase, N-terminal
IPR006561
DZF domain
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PFAM |
PF07528
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PRINTS |
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PIRSF |
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SMART |
SM00572
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TIGRFAMs |
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Modification |
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SwissProt |
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PhosphoSite |
PhosphoSite-Q12905
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3608
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UniGene |
Hs.75117
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RefSeq |
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HUGO |
HGNC:6037
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OMIM |
603181
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CCDS |
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HPRD |
04419
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IMGT |
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EMBL |
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GenPept |
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