InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NPR1

Summary

InnateDB Protein

IDBP-102771.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NPR1

Protein Name

natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)

Synonyms

ANPa; ANPRA; GUC2A; GUCY2A; NPRA;

Species

Homo sapiens

Ensembl Protein

ENSP00000357669

InnateDB Gene

IDBG-102769 (NPR1)

Protein Structure

UniProt Annotation

Function

Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. {ECO:0000269PubMed:1672777}.

Subcellular Localization

Membrane; Single-pass type I membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004383	guanylate cyclase activity
GO:0004672	protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0005525	GTP binding
GO:0008528	G-protein coupled peptide receptor activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016849	phosphorus-oxygen lyase activity
GO:0016941	natriuretic peptide receptor activity
GO:0017046	peptide hormone binding
GO:0019901	protein kinase binding
GO:0042562	hormone binding

Biological Process

GO:0006182	cGMP biosynthetic process
GO:0006468	protein phosphorylation
GO:0007166	cell surface receptor signaling pathway
GO:0007168	receptor guanylyl cyclase signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007589	body fluid secretion
GO:0008217	regulation of blood pressure
GO:0009190	cyclic nucleotide biosynthetic process
GO:0016525	negative regulation of angiogenesis
GO:0030308	negative regulation of cell growth
GO:0030828	positive regulation of cGMP biosynthetic process
GO:0035556	intracellular signal transduction
GO:0035810	positive regulation of urine volume
GO:0035815	positive regulation of renal sodium excretion
GO:0042312	regulation of vasodilation
GO:0042417	dopamine metabolic process
GO:0043114	regulation of vascular permeability
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050880	regulation of blood vessel size

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001054 Adenylyl cyclase class-3/4/guanylyl cyclase
IPR001170 Natriuretic peptide receptor
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001828 Extracellular ligand-binding receptor
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
IPR028082 Periplasmic binding protein-like I
IPR029787 Nucleotide cyclase

PFAM

PF00069
PF00211
PF07714
PF01094

PRINTS

PR00255
PR00109

PIRSF

SMART

SM00044
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt