Version 5.4
Homo sapiens Protein: DENND4B
Summary
InnateDB Protein IDBP-102802.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DENND4B
Protein Name DENN/MADD domain containing 4B
Synonyms KIAA0476;
Species Homo sapiens
Ensembl Protein ENSP00000354597
InnateDB Gene IDBG-102798 (DENND4B)
Protein Structure
UniProt Annotation
Function Guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. {ECO:0000269PubMed:20937701}.
Subcellular Localization Golgi apparatus {ECO:0000269PubMed:20937701}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0017112 Rab guanyl-nucleotide exchange factor activity
Biological Process
GO:0032483 regulation of Rab protein signal transduction
GO:0032851 positive regulation of Rab GTPase activity
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID
InterPro IPR001194 DENN domain
IPR005112 dDENN domain
IPR005113 uDENN domain
PFAM PF02141
PF03455
PF03456
PRINTS
PIRSF
SMART SM00799
SM00801
SM00800
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75064
PhosphoSite PhosphoSite-O75064
TrEMBL
UniProt Splice Variant
Entrez Gene 9909
UniGene Hs.728814
RefSeq NP_055671
HUGO HGNC:29044
OMIM
CCDS CCDS44228
HPRD
IMGT
EMBL AB007945 AL358472 CH471121
GenPept BAA32321 CAI14016 EAW53268

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca