InnateDB Protein
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IDBP-102991.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PBXIP1
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Protein Name
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pre-B-cell leukemia homeobox interacting protein 1
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000357448
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InnateDB Gene
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IDBG-102985 (PBXIP1)
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Protein Structure
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Function |
Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling. {ECO:0000269PubMed:10825160, ECO:0000269PubMed:12360403, ECO:0000269PubMed:17043237}.
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Subcellular Localization |
Cytoplasm, cytoskeleton. Nucleus. Note=Shuttles between the nucleus and the cytosol. Mainly localized in the cytoplasm, associated with microtubules. Detected in small amounts in the nucleus.
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Disease Associations |
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Tissue Specificity |
Expressed in early hematopoietic precursors. {ECO:0000269PubMed:10825160}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
16
[view]
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Protein-Protein |
16
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q96AQ6
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PhosphoSite |
PhosphoSite-Q96AQ6
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TrEMBL |
F5H2F6
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UniProt Splice Variant |
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Entrez Gene |
57326
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UniGene |
Hs.505806
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RefSeq |
NP_065385
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HUGO |
HGNC:21199
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OMIM |
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CCDS |
CCDS1074
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HPRD |
17823
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IMGT |
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EMBL |
AF221521
AK022497
AK023219
AL451085
BC016852
CH471121
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GenPept |
AAG02026
AAH16852
BAB14059
BAB14471
CAI13238
CAI13239
CAI13240
EAW53175
EAW53176
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