InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MUC1

Summary

InnateDB Protein

IDBP-103138.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MUC1

Protein Name

mucin 1, cell surface associated

Synonyms

ADMCKD; ADMCKD1; CA 15-3; CD227; EMA; H23AG; KL-6; MAM6; MCD; MCKD; MCKD1; MUC-1; MUC-1/SEC; MUC-1/X; MUC1/ZD; PEM; PEMT; PUM;

Species

Homo sapiens

Ensembl Protein

ENSP00000357378

InnateDB Gene

IDBG-103122 (MUC1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	69 [view]
Protein-Protein	67 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0002039	p53 binding
GO:0003712	transcription cofactor activity
GO:0005515	protein binding

Biological Process

GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0006978	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0010944	negative regulation of transcription by competitive promoter binding
GO:0016266	O-glycan processing
GO:0036003	positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043618	regulation of transcription from RNA polymerase II promoter in response to stress
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0090240	positive regulation of histone H4 acetylation
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Cellular Component

GO:0000790	nuclear chromatin
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005796	Golgi lumen
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016324	apical plasma membrane
GO:0070062	extracellular vesicular exosome