Version 5.4
| Homo sapiens Protein: SLC28A2 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-10320.6 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | SLC28A2 | ||||||||
| Protein Name | solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 | ||||||||
| Synonyms | CNT2; HCNT2; HsT17153; SPNT1; | ||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000315006 | ||||||||
| InnateDB Gene | IDBG-10318 (SLC28A2) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues. | ||||||||
| Subcellular Localization | Membrane; Multi-pass membrane protein. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR002668
Concentrative nucleoside transporter N-terminal domain IPR011642 Nucleoside recognition Gate IPR011657 Concentrative nucleoside transporter C-terminal domain IPR018270 Concentrative nucleoside transporter, metazoan/bacterial |
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| PFAM |
PF01773
PF07670 PF07662 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART | |||||||||
| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | O43868 | ||||||||
| PhosphoSite | PhosphoSite-O43868 | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 9153 | ||||||||
| UniGene | Hs.367833 | ||||||||
| RefSeq | NP_004203 | ||||||||
| HUGO | HGNC:11002 | ||||||||
| OMIM | 606208 | ||||||||
| CCDS | CCDS10121 | ||||||||
| HPRD | 07069 | ||||||||
| IMGT | |||||||||
| EMBL | AF036109 AK291974 BC093737 U84392 | ||||||||
| GenPept | AAB88539 AAC51930 AAH93737 BAF84663 | ||||||||