Homo sapiens Protein: CLK2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Protein | IDBP-103226.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | CLK2 | ||||||||||||||||||
Protein Name | CDC-like kinase 2 | ||||||||||||||||||
Synonyms | |||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Protein | ENSP00000357345 | ||||||||||||||||||
InnateDB Gene | IDBG-103224 (CLK2) | ||||||||||||||||||
Protein Structure | |||||||||||||||||||
UniProt Annotation | |||||||||||||||||||
Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Acts as a suppressor of hepatic gluconeogenesis and glucose output by repressing PPARGC1A transcriptional activity on gluconeogenic genes via its phosphorylation. Phosphorylates PPP2R5B thereby stimulating the assembly of PP2A phosphatase with the PPP2R5B-AKT1 complex leading to dephosphorylation of AKT1. Phosphorylates: PTPN1, SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. {ECO:0000269PubMed:10480872, ECO:0000269PubMed:19168442, ECO:0000269PubMed:8910305, ECO:0000269PubMed:9637771}. | ||||||||||||||||||
Subcellular Localization | Isoform 1: Nucleus. Nucleus speckle. Note=Inhibition of phosphorylation at Ser-142 results in accumulation in the nuclear speckle. {ECO:0000250}.Isoform 2: Nucleus speckle. Note=Co- localizes with serine- and arginine-rich (SR) proteins in the nuclear speckles. | ||||||||||||||||||
Disease Associations | |||||||||||||||||||
Tissue Specificity | Endothelial cells. {ECO:0000269PubMed:19168442}. | ||||||||||||||||||
Comments | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||
PDB ID | |||||||||||||||||||
InterPro |
IPR000719
Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR011009 Protein kinase-like domain IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00069
PF07714 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||
SMART |
SM00220
SM00219 |
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TIGRFAMs | |||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||
Modification | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | P49760 | ||||||||||||||||||
PhosphoSite | PhosphoSite-P49760 | ||||||||||||||||||
TrEMBL | Q9BRG8 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 1196 | ||||||||||||||||||
UniGene | Hs.73986 | ||||||||||||||||||
RefSeq | NP_001281268 | ||||||||||||||||||
HUGO | HGNC:2069 | ||||||||||||||||||
OMIM | 602989 | ||||||||||||||||||
CCDS | CCDS72939 | ||||||||||||||||||
HPRD | 04289 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AF023268 AK291995 AK303696 AL713999 BC006274 BC014067 BC053603 CH471121 L29216 L29218 | ||||||||||||||||||
GenPept | AAA61481 AAA61482 AAC51817 AAH06274 AAH14067 AAH53603 BAF84684 BAH14022 CAI95098 EAW53087 EAW53089 | ||||||||||||||||||