InnateDB Protein
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IDBP-10323.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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RNPS1
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Protein Name
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RNA binding protein S1, serine-rich domain
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Synonyms
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E5.1;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000315859
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InnateDB Gene
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IDBG-10321 (RNPS1)
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Protein Structure
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Function |
Part of pre- and post-splicing multiprotein mRNP complexes. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Enhances the formation of the ATP-dependent A complex of the spliceosome. Involved in both constitutive splicing and, in association with SRP54 and TRA2B/SFRS10, in distinctive modulation of alternative splicing in a substrate-dependent manner. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Participates in mRNA 3'-end cleavage. Involved in UPF2- dependent nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Also mediates increase of mRNA abundance and translational efficiency. Binds spliced mRNA 20-25 nt upstream of exon-exon junctions. {ECO:0000269PubMed:10449421, ECO:0000269PubMed:11546874, ECO:0000269PubMed:12665594, ECO:0000269PubMed:12944400, ECO:0000269PubMed:14729963, ECO:0000269PubMed:14752011, ECO:0000269PubMed:15684395, ECO:0000269PubMed:16209946, ECO:0000269PubMed:17586820, ECO:0000269PubMed:22203037}.
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Subcellular Localization |
Nucleus. Nucleus speckle. Cytoplasm. Note=Nucleocytoplasmic shuttling protein. Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and UAP56 in the nucleus and nuclear speckles.
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Disease Associations |
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Tissue Specificity |
Ubiquitous. {ECO:0000269PubMed:8543184}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 145 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
145
[view]
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Protein-Protein |
142
[view]
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Protein-DNA |
3
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000504
RNA recognition motif domain
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PFAM |
PF00076
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PRINTS |
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PIRSF |
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SMART |
SM00360
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TIGRFAMs |
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Modification |
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SwissProt |
Q15287
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PhosphoSite |
PhosphoSite-Q15287
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TrEMBL |
H3BUL0
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UniProt Splice Variant |
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Entrez Gene |
10921
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UniGene |
Hs.736362
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RefSeq |
NP_542161
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HUGO |
HGNC:10080
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OMIM |
606447
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CCDS |
CCDS10465
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HPRD |
07341
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IMGT |
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EMBL |
AB445101
AC009065
AF015608
AF247662
AF274003
AK289955
AK293343
AK303100
AK316132
BC001659
BC001838
BC108316
CH471112
L37368
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GenPept |
AAA92859
AAC39791
AAF72519
AAH01659
AAH01838
AAI08317
AAL56665
BAF82644
BAG56859
BAG64209
BAH14503
BAI99736
EAW85516
EAW85517
EAW85519
EAW85520
EAW85522
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