Version 5.4
Homo sapiens Protein: HCN3
Summary
InnateDB Protein IDBP-103233.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HCN3
Protein Name hyperpolarization activated cyclic nucleotide-gated potassium channel 3
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357342
InnateDB Gene IDBG-103231 (HCN3)
Protein Structure
UniProt Annotation
Function Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. {ECO:0000269PubMed:16043489}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:16043489}; Multi-pass membrane protein {ECO:0000269PubMed:16043489}.
Disease Associations
Tissue Specificity Detected in brain. {ECO:0000269PubMed:16043489}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005248 voltage-gated sodium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0030552 cAMP binding
Biological Process
GO:0006811 ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0035725 sodium ion transmembrane transport
GO:0042391 regulation of membrane potential
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000595 Cyclic nucleotide-binding domain
IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
IPR005821 Ion transport domain
IPR013621 Ion transport N-terminal
IPR018490 Cyclic nucleotide-binding-like
PFAM PF00027
PF00520
PF08412
PRINTS PR01463
PIRSF
SMART SM00100
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P1Z3
PhosphoSite PhosphoSite-Q9P1Z3
TrEMBL
UniProt Splice Variant
Entrez Gene 57657
UniGene Hs.706960
RefSeq NP_065948
HUGO HGNC:19183
OMIM 609973
CCDS CCDS1108
HPRD 17093
IMGT
EMBL AB040968 AL713999 BC000066 BC028024 CH471121
GenPept AAH00066 AAH28024 BAA96059 CAI95100 EAW53084 EAW53086

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca