InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: UBQLN4

Summary

InnateDB Protein

IDBP-103360.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBQLN4

Protein Name

ubiquilin 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000357292

InnateDB Gene

IDBG-103358 (UBQLN4)

Protein Structure

UniProt Annotation

Function

Plays a role in the regulation of proteasomal protein degradation. Depending on the case, may promote or inhibit proteasomal protein degradation. {ECO:0000269PubMed:15280365}.

Subcellular Localization

Nucleus. Cytoplasm. Endoplasmic reticulum {ECO:0000305}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Colocalizes with the proteasome, both in nucleus and cytoplasm. May associate with the endoplasmic reticulum.

Disease Associations

Tissue Specificity

Highly expressed in pancreas, kidney, skeletal muscle, heart and throughout the brain, and at lower levels in placenta, lung and liver. {ECO:0000269PubMed:11001934}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 200 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	201 [view]
Protein-Protein	201 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003684	damaged DNA binding
GO:0005488	binding
GO:0005515	protein binding
GO:0031593	polyubiquitin binding
GO:0042802	identical protein binding

Biological Process

GO:0006289	nucleotide-excision repair
GO:0032434	regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0005813	centrosome
GO:0005829	cytosol
GO:0031595	nuclear proteasome complex
GO:0031597	cytosolic proteasome complex
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000626 Ubiquitin-like
IPR006636 Heat shock chaperonin-binding
IPR009060 UBA-like
IPR015360 XPC-binding domain
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold
IPR022617 Rad60/SUMO-like domain
IPR029071 Ubiquitin-related domain

PFAM

PF00627
PF00240
PF14560
PF09280
PF11976

PRINTS

PIRSF

SMART

SM00213
SM00727
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9NRR5