InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BGLAP

Summary

InnateDB Protein

IDBP-103429.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BGLAP

Protein Name

bone gamma-carboxyglutamate (gla) protein

Synonyms

BGP; OC; OCN;

Species

Homo sapiens

Ensembl Protein

ENSP00000357255

InnateDB Gene

IDBG-408869 (BGLAP)

Protein Structure

UniProt Annotation

Function

Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005509	calcium ion binding
GO:0008147	structural constituent of bone
GO:0046848	hydroxyapatite binding

Biological Process

GO:0001501	skeletal system development
GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0002076	osteoblast development
GO:0007155	cell adhesion
GO:0007568	aging
GO:0007569	cell aging
GO:0009612	response to mechanical stimulus
GO:0009629	response to gravity
GO:0010035	response to inorganic substance
GO:0010043	response to zinc ion
GO:0014070	response to organic cyclic compound
GO:0014823	response to activity
GO:0030282	bone mineralization
GO:0030500	regulation of bone mineralization
GO:0031667	response to nutrient levels
GO:0032571	response to vitamin K
GO:0033280	response to vitamin D
GO:0033574	response to testosterone
GO:0033594	response to hydroxyisoflavone
GO:0042476	odontogenesis
GO:0042493	response to drug
GO:0043627	response to estrogen
GO:0045124	regulation of bone resorption
GO:0045471	response to ethanol
GO:0045670	regulation of osteoclast differentiation
GO:0051384	response to glucocorticoid
GO:0060348	bone development
GO:0071305	cellular response to vitamin D
GO:0071363	cellular response to growth factor stimulus

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0030425	dendrite
GO:0031988	membrane-bounded vesicle
GO:0042995	cell projection
GO:0043204	perikaryon