Version 5.4
| Homo sapiens Protein: LGI3 | |||||||||
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| Summary | |||||||||
| InnateDB Protein | IDBP-10345.5 | ||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
| Gene Symbol | LGI3 | ||||||||
| Protein Name | leucine-rich repeat LGI family, member 3 | ||||||||
| Synonyms | |||||||||
| Species | Homo sapiens | ||||||||
| Ensembl Protein | ENSP00000302297 | ||||||||
| InnateDB Gene | IDBG-10343 (LGI3) | ||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||
| Function | May participate in the regulation of neuronal exocytosis. {ECO:0000250}. | ||||||||
| Subcellular Localization | Secreted {ECO:0000305}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250}. Note=Found in the synaptosomal membrane fraction. {ECO:0000250}. | ||||||||
| Disease Associations | |||||||||
| Tissue Specificity | Widely expressed, with highest levels in brain and lung. {ECO:0000269PubMed:12023020}. | ||||||||
| Comments | |||||||||
| Interactions | |||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||
| PDB ID | |||||||||
| InterPro |
IPR000483
Cysteine-rich flanking region, C-terminal IPR003591 Leucine-rich repeat, typical subtype IPR005492 Leucine-rich glioma-inactivated , EPTP repeat IPR009039 EAR |
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| PFAM |
PF01463
PF03736 |
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| PRINTS | |||||||||
| PIRSF | |||||||||
| SMART |
SM00082
SM00369 |
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| TIGRFAMs | |||||||||
| Post-translational Modifications | |||||||||
| Modification | |||||||||
| Cross-References | |||||||||
| SwissProt | Q8N145 | ||||||||
| PhosphoSite | PhosphoSite- | ||||||||
| TrEMBL | |||||||||
| UniProt Splice Variant | |||||||||
| Entrez Gene | 203190 | ||||||||
| UniGene | Hs.33470 | ||||||||
| RefSeq | NP_644807 | ||||||||
| HUGO | HGNC:18711 | ||||||||
| OMIM | 608302 | ||||||||
| CCDS | CCDS6025 | ||||||||
| HPRD | 06432 | ||||||||
| IMGT | |||||||||
| EMBL | AF467956 AJ487518 AJ487961 AK090946 AY358116 BC042542 | ||||||||
| GenPept | AAH42542 AAM49554 AAQ88483 BAC03553 CAD31786 CAD32308 | ||||||||