Version 5.4
Homo sapiens Protein: BCAN
Summary
InnateDB Protein IDBP-103576.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BCAN
Protein Name brevican
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000354925
InnateDB Gene IDBG-103570 (BCAN)
Protein Structure
UniProt Annotation
Function May play a role in the terminally differentiating and the adult nervous system during postnatal development. Could stabilize interactions between hyaluronan (HA) and brain proteoglycans.
Subcellular Localization Isoform 1: Secreted, extracellular space, extracellular matrix.Isoform 2: Membrane; Lipid-anchor, GPI- anchor.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
GO:0030246 carbohydrate binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0007155 cell adhesion
GO:0022617 extracellular matrix disassembly
GO:0030198 extracellular matrix organization
GO:0030203 glycosaminoglycan metabolic process
GO:0030204 chondroitin sulfate metabolic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0030207 chondroitin sulfate catabolic process
GO:0030208 dermatan sulfate biosynthetic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005796 Golgi lumen
GO:0031225 anchored component of membrane
GO:0043202 lysosomal lumen
Protein Structure and Domains
PDB ID
InterPro IPR000538 Link
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold
PFAM PF00193
PF07686
PRINTS PR01265
PIRSF
SMART SM00445
SM00406
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96GW7
PhosphoSite PhosphoSite-Q96GW7
TrEMBL Q5T3I8
UniProt Splice Variant
Entrez Gene 63827
UniGene Hs.516904
RefSeq NP_940819
HUGO HGNC:23059
OMIM
CCDS CCDS1150
HPRD 09821
IMGT
EMBL AF228710 AF229053 AL365181 AL590666 AY358372 BC009117 BC022938 BC027971 CH471121
GenPept AAG23134 AAG23135 AAH09117 AAH22938 AAH27971 AAQ88738 CAI13056 CAI13060 CAI16352 EAW52927 EAW52928 EAW52929 EAW52930

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca