Version 5.4
Homo sapiens Protein: ISG20L2
Summary
InnateDB Protein IDBP-103597.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ISG20L2
Protein Name interferon stimulated exonuclease gene 20kDa-like 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000323424
InnateDB Gene IDBG-103591 (ISG20L2)
Protein Structure
UniProt Annotation
Function 3'-> 5'-exoribonuclease involved in ribosome biogenesis in the processing of the 12S pre-rRNA. Displays a strong specificity for a 3'-end containing a free hydroxyl group. {ECO:0000269PubMed:18065403}.
Subcellular Localization Nucleus, nucleolus {ECO:0000269PubMed:12429849, ECO:0000269PubMed:18065403}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0042254 ribosome biogenesis
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005730 nucleolus
Protein Structure and Domains
PDB ID
InterPro IPR006055 Exonuclease
IPR012337 Ribonuclease H-like domain
IPR013520 Exonuclease, RNase T/DNA polymerase III
PFAM PF00929
PRINTS
PIRSF
SMART SM00479
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H9L3
PhosphoSite PhosphoSite-Q9H9L3
TrEMBL
UniProt Splice Variant
Entrez Gene 81875
UniGene Hs.301904
RefSeq NP_112242
HUGO HGNC:25745
OMIM 611930
CCDS CCDS1153
HPRD 07788
IMGT
EMBL AK022733 AL590666 AY391837 BC000575 CH471121
GenPept AAH00575 AAS55433 BAB14212 CAI16341 EAW52919 EAW52920

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca