InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEAR1

Summary

InnateDB Protein

IDBP-103644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEAR1

Protein Name

platelet endothelial aggregation receptor 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000344465

InnateDB Gene

IDBG-103642 (PEAR1)

Protein Structure

UniProt Annotation

Function

When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. {ECO:0000250}.

Subcellular Localization

Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Detected on the cell surface in resting platelets. {ECO:0000269PubMed:15851471}.

Disease Associations

Tissue Specificity

Expressed in umbilical vein endothelial cells and platelets (at protein level). Expressed in heart, kidney, skeletal muscle, pancreas, ovary, breast, lung, brain cortex, hypothalamus, spinal cord, dorsal root ganglion, endothelial cells of umbilical cord artery and vein, megakaryocytes, osteoblasts, coronary muscle and erythroid cells. Weakly expressed in peripheral blood leukocytes and macrophages.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0043654

recognition of apoptotic cell

Cellular Component

GO:0001891	phagocytic cup
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000742 Epidermal growth factor-like domain
IPR002049 EGF-like, laminin
IPR009030 Insulin-like growth factor binding protein, N-terminal
IPR011489 EMI domain

PFAM

PF00008
PF00053
PF07546

PRINTS

PIRSF

SMART

SM00181
SM00180

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q5VY43