InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SFTPC

Summary

InnateDB Protein

IDBP-10370.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SFTPC

Protein Name

surfactant protein C

Synonyms

BRICD6; PSP-C; SFTP2; SMDP2; SP-C;

Species

Homo sapiens

Ensembl Protein

ENSP00000316152

InnateDB Gene

IDBG-10368 (SFTPC)

Protein Structure

UniProt Annotation

Function

Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces.

Subcellular Localization

Secreted, extracellular space, surface film.

Disease Associations

Pulmonary surfactant metabolism dysfunction 2 (SMDP2) [MIM:610913]: A rare disease associated with progressive respiratory insufficiency and lung disease with a variable clinical course, due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. {ECO:0000269PubMed:11991887, ECO:0000269PubMed:15039969, ECO:0000269PubMed:15293602, ECO:0000269PubMed:15557112, ECO:0000269PubMed:15572558}. Note=The disease is caused by mutations affecting the gene represented in this entry.Respiratory distress syndrome in premature infants (RDS) [MIM:267450]: A lung disease affecting usually premature newborn infants. It is characterized by deficient gas exchange, diffuse atelectasis, high-permeability lung edema and fibrin-rich alveolar deposits called 'hyaline membranes'. {ECO:0000269PubMed:14735158}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007585	respiratory gaseous exchange
GO:0007623	circadian rhythm
GO:0009725	response to hormone
GO:0009749	response to glucose
GO:0010033	response to organic substance
GO:0032496	response to lipopolysaccharide
GO:0032526	response to retinoic acid
GO:0033189	response to vitamin A
GO:0051260	protein homooligomerization
GO:0051384	response to glucocorticoid
GO:0051591	response to cAMP
GO:0055093	response to hyperoxia
GO:0070741	response to interleukin-6
GO:0070848	response to growth factor
GO:0071260	cellular response to mechanical stimulus
GO:0071732	cellular response to nitric oxide