Version 5.4
Homo sapiens Protein: FCRL1
Summary
InnateDB Protein IDBP-103713.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCRL1
Protein Name Fc receptor-like 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357158
InnateDB Gene IDBG-103709 (FCRL1)
Protein Structure
UniProt Annotation
Function May function as an activating coreceptor in B-cells. May function in B-cells activation and differentiation. {ECO:0000269PubMed:15479727}.
Subcellular Localization Cell membrane {ECO:0000269PubMed:15479727, ECO:0000269PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269PubMed:15479727, ECO:0000269PubMed:16849395}.
Disease Associations
Tissue Specificity Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, heart, skeletal muscle, kidney, liver and placenta. Specifically expressed by mature B lineage cells with higher expression in naive versus memory B-cells (at protein level). {ECO:0000269PubMed:11493702, ECO:0000269PubMed:11929751, ECO:0000269PubMed:15479727, ECO:0000269PubMed:16849395}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003598 Immunoglobulin subtype 2
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
PFAM PF07679
PRINTS
PIRSF
SMART SM00408
SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LA6
PhosphoSite PhosphoSite-Q96LA6
TrEMBL
UniProt Splice Variant
Entrez Gene 115350
UniGene Hs.656112
RefSeq NP_443170
HUGO HGNC:18509
OMIM 606508
CCDS CCDS1170
HPRD 07350
IMGT
EMBL AF329488 AK096690 AK315748 AL139409 AL356276 AL833970 AY043464 BC033690 CH471121 EF064734
GenPept AAH33690 AAK91777 AAL23898 ABK41917 BAC04842 BAG38102 CAD38815 CAH70232 CAH70233 CAH70234 CAH73052 CAH73053 CAH73054 EAW52861 EAW52862

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca