Version 5.4
Homo sapiens Protein: CD1B
Summary
InnateDB Protein IDBP-103746.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD1B
Protein Name CD1b molecule
Synonyms CD1; CD1A; R1;
Species Homo sapiens
Ensembl Protein ENSP00000357150
InnateDB Gene IDBG-103744 (CD1B)
Protein Structure
UniProt Annotation
Function Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. {ECO:0000269PubMed:10981968, ECO:0000269PubMed:14716313}.
Subcellular Localization Cell membrane; Single-pass type I membrane protein. Endosome membrane. Lysosome membrane. Note=Subject to intracellular trafficking between the cell membrane, endosomes and lysosomes. Localizes to cell surface lipid rafts.
Disease Associations
Tissue Specificity Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006955 immune response
GO:0019882 antigen processing and presentation
Cellular Component
GO:0005765 lysosomal membrane
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR003597 Immunoglobulin C1-set
IPR007110 Immunoglobulin-like domain
IPR011162 MHC classes I/II-like antigen recognition protein
PFAM PF07654
PRINTS
PIRSF
SMART SM00407
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P29016
PhosphoSite PhosphoSite-P29016
TrEMBL Q9UN97
UniProt Splice Variant
Entrez Gene 910
UniGene
RefSeq NP_001755
HUGO HGNC:1635
OMIM 188360
CCDS CCDS1176
HPRD 01775
IMGT
EMBL AF142666 AK303330 AL121986 BC069481 BC074747 BC104216 BC104217 M14665 M22168 M22169 M22170 M22171 M22172 M22173 M28826
GenPept AAA51936 AAA51939 AAA51940 AAD37579 AAH69481 AAH74747 AAI04217 AAI04218 BAG64395 CAI10852 CAI10853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca