InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AIM2

Summary

InnateDB Protein

IDBP-103865.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AIM2

Protein Name

absent in melanoma 2

Synonyms

PYHIN4;

Species

Homo sapiens

Ensembl Protein

ENSP00000357112

InnateDB Gene

IDBG-103863 (AIM2)

Protein Structure

UniProt Annotation

Function

Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 (By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. {ECO:0000250, ECO:0000269PubMed:16432157, ECO:0000269PubMed:17726700, ECO:0000269PubMed:19158675, ECO:0000269PubMed:19158676, ECO:0000269PubMed:19158679, ECO:0000269PubMed:20566831}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles.

Disease Associations

Tissue Specificity

Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. {ECO:0000269PubMed:9242382}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	6 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003690	double-stranded DNA binding
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0002218	activation of innate immune response
GO:0002230	positive regulation of defense response to virus by host
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0032088	negative regulation of NF-kappaB transcription factor activity
GO:0032461	positive regulation of protein oligomerization
GO:0032731	positive regulation of interleukin-1 beta production
GO:0033209	tumor necrosis factor-mediated signaling pathway
GO:0035458	cellular response to interferon-beta
GO:0035690	cellular response to drug
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0050702	interleukin-1 beta secretion
GO:0050718	positive regulation of interleukin-1 beta secretion
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0070269	pyroptosis
GO:2001056	positive regulation of cysteine-type endopeptidase activity