InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CASQ1

Summary

InnateDB Protein

IDBP-104007.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CASQ1

Protein Name

calsequestrin 1 (fast-twitch, skeletal muscle)

Synonyms

CASQ; PDIB1;

Species

Homo sapiens

Ensembl Protein

ENSP00000357057

InnateDB Gene

IDBG-104003 (CASQ1)

Protein Structure

UniProt Annotation

Function

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+).

Subcellular Localization

Sarcoplasmic reticulum lumen. Mitochondrion. Note=This isoform of calsequestrin occurs in the sarcoplasmic reticulum's terminal cisternae luminal spaces of fast skeletal muscle cells. Also mitochondrial according to PubMed:7945294.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding

Biological Process

GO:0007029	endoplasmic reticulum organization
GO:0007519	skeletal muscle tissue development
GO:0009408	response to heat
GO:0010033	response to organic substance
GO:0010880	regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
GO:0014809	regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
GO:0014870	response to muscle inactivity
GO:0014894	response to denervation involved in regulation of muscle adaptation
GO:0034220	ion transmembrane transport
GO:0051282	regulation of sequestering of calcium ion
GO:0055085	transmembrane transport

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix
GO:0005783	endoplasmic reticulum
GO:0005790	smooth endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0014802	terminal cisterna
GO:0014804	terminal cisterna lumen
GO:0016529	sarcoplasmic reticulum
GO:0030016	myofibril
GO:0030315	T-tubule
GO:0031674	I band
GO:0033017	sarcoplasmic reticulum membrane
GO:0033018	sarcoplasmic reticulum lumen
GO:0042383	sarcolemma
GO:0043231	intracellular membrane-bounded organelle