InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEA15

Summary

InnateDB Protein

IDBP-104010.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEA15

Protein Name

phosphoprotein enriched in astrocytes 15

Synonyms

HMAT1; HUMMAT1H; MAT1; MAT1H; PEA-15; PED;

Species

Homo sapiens

Ensembl Protein

ENSP00000353660

InnateDB Gene

IDBG-104008 (PEA15)

Protein Structure

UniProt Annotation

Function

Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm (By similarity). Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface. {ECO:0000250, ECO:0000269PubMed:10442631, ECO:0000269PubMed:9670003}.

Subcellular Localization

Cytoplasm. Note=Associated with microtubules.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Most abundant in tissues such as heart, brain, muscle and adipose tissue which utilize glucose as an energy source. Lower expression in glucose- producing tissues. Higher levels of expression are found in tissues from individuals with type 2 diabetes than in controls. {ECO:0000269PubMed:9670003}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006810	transport
GO:0006915	apoptotic process
GO:0008643	carbohydrate transport
GO:0042981	regulation of apoptotic process
GO:0046325	negative regulation of glucose import
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors