InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CD48

Summary

InnateDB Protein

IDBP-104082.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD48

Protein Name

CD48 molecule

Synonyms

BCM1; BLAST; BLAST1; hCD48; mCD48; MEM-102; SLAMF2;

Species

Homo sapiens

Ensembl Protein

ENSP00000357025

InnateDB Gene

IDBG-104080 (CD48)

Protein Structure

UniProt Annotation

Function

Ligand for CD2. Might facilitate interaction between activated lymphocytes. Probably involved in regulating T-cell activation.

Subcellular Localization

Cell membrane {ECO:0000250}; Lipid-anchor, GPI-anchor {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding

Biological Process

GO:0006952	defense response
GO:0007596	blood coagulation
GO:0050900	leukocyte migration

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain

PFAM

PF07686

PRINTS

PIRSF

SMART

SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P09326

PhosphoSite

PhosphoSite-P09326

TrEMBL

UniProt Splice Variant

Entrez Gene

962

UniGene

Hs.243564

RefSeq

NP_001769

HUGO

HGNC:1683

OMIM

109530

CCDS

CCDS1208

HPRD

00177

IMGT

EMBL

AL121985 BC016182 BT019813 CH471121 M37766 M59904 M63911 X06341

GenPept

AAA35602 AAA36211 AAA62834 AAH16182 AAV38616 CAA29647 CAC00578 EAW52705