InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ITLN1

Summary

InnateDB Protein

IDBP-104125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITLN1

Protein Name

intelectin 1 (galactofuranose binding)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323587

InnateDB Gene

IDBG-104123 (ITLN1)

Protein Structure

UniProt Annotation

Function

Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism. {ECO:0000269PubMed:11313366, ECO:0000269PubMed:16531507}.

Subcellular Localization

Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Enriched in lipid rafts. {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in omental adipose tissue where it is found in stromal vascular cells but not in fat cells but is barely detectable in subcutaneous adipose tissue (at protein level). Highly expressed in the small intestine. Also found in the heart, testis, colon, salivary gland, skeletal muscle, pancreas and thyroid and, to a lesser degree, in the uterus, spleen, prostate, lymph node and thymus. {ECO:0000269PubMed:11181563, ECO:0000269PubMed:11313366, ECO:0000269PubMed:11747454, ECO:0000269PubMed:16531507}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0009624	response to nematode
GO:0046326	positive regulation of glucose import

Cellular Component

GO:0031225	anchored component of membrane
GO:0031526	brush border membrane
GO:0043235	receptor complex
GO:0045121	membrane raft
GO:0070062	extracellular vesicular exosome