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InnateDB Protein
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IDBP-104141.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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F11R
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Protein Name
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F11 receptor
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000289779
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InnateDB Gene
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IDBG-104131 (F11R)
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Protein Structure
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| Function |
Seems to play a role in epithelial tight junction formation. Appears early in primordial forms of cell junctions and recruits PARD3. The association of the PARD6-PARD3 complex may prevent the interaction of PARD3 with JAM1, thereby preventing tight junction assembly (By similarity). Plays a role in regulating monocyte transmigration involved in integrity of epithelial barrier. Involved in platelet activation. In case of orthoreovirus infection, serves as receptor for the virus. {ECO:0000250}.
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| Subcellular Localization |
Cell junction, tight junction {ECO:0000269PubMed:11171323}. Cell membrane {ECO:0000269PubMed:11171323}; Single-pass type I membrane protein {ECO:0000269PubMed:11171323}. Note=Localized at tight junctions of both epithelial and endothelial cells.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
20
[view]
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| Protein-Protein |
18
[view]
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| Protein-DNA |
1
[view]
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
1
[view]
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| Predicted by orthology |
| Total |
1 [view]
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| PDB ID |
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| InterPro |
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-Q9Y624
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
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| UniGene |
Hs.678890
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| RefSeq |
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
12038
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| IMGT |
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| EMBL |
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| GenPept |
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Version 5.4