Version 5.4
Homo sapiens Protein: TSTD1
Summary
InnateDB Protein IDBP-104147.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TSTD1
Protein Name thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000357002
InnateDB Gene IDBG-226903 (TSTD1)
Protein Structure
UniProt Annotation
Function Possible role in tumorigenesis.
Subcellular Localization Cytoplasm, perinuclear region {ECO:0000269PubMed:12817473}. Note=Localized around the nuclear membranes.
Disease Associations
Tissue Specificity Highly expressed in kidney, liver and skeletal muscle. Lower levels of expression in heart, colon, thymus, spleen, placenta and lung. Weakly expressed in brain, small intestine and peripheral blood leukocytes. Expressed at high levels in the breast carcinoma cell lines MCF-7 and MDA-MB-468 and at a lower level in the breast carcinoma cell line MDA-MB-231, the colon carcinoma call line LoVo and the lung carcinoma cell line A- 549. No expression in the cell lines EFO-27 and HeLa, or the normal breast tissue cell lines MCF-10A and H184A1. Detected in invasive ductal carcinoma, but not in the adjacent tissues. {ECO:0000269PubMed:12817473}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001763 Rhodanese-like domain
PFAM PF00581
PRINTS
PIRSF
SMART SM00450
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8NFU3
PhosphoSite PhosphoSite-Q8NFU3
TrEMBL R4GNF9
UniProt Splice Variant
Entrez Gene 100131187
UniGene
RefSeq
HUGO HGNC:35410
OMIM
CCDS
HPRD
IMGT
EMBL AF439442 AL591806 BC001699
GenPept AAH01699 AAM69839 AAM69840 CAI15367 CAI15368 CAI15369 CAI15370

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca