InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PFDN2

Summary

InnateDB Protein

IDBP-104180.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFDN2

Protein Name

prefoldin subunit 2

Synonyms

PFD2;

Species

Homo sapiens

Ensembl Protein

ENSP00000356989

InnateDB Gene

IDBG-104178 (PFDN2)

Protein Structure

UniProt Annotation

Function

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269PubMed:9630229}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:17936702}. Cytoplasm {ECO:0000269PubMed:17936702}. Mitochondrion {ECO:0000269PubMed:17936702}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0051082	unfolded protein binding

Biological Process

GO:0006457	protein folding
GO:0044267	cellular protein metabolic process
GO:0051084	'de novo' posttranslational protein folding

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0016272	prefoldin complex
GO:0070062	extracellular vesicular exosome