Version 5.4
Homo sapiens Protein: CEP72
Summary
InnateDB Protein IDBP-10421.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP72
Protein Name centrosomal protein 72kDa
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000264935
InnateDB Gene IDBG-10419 (CEP72)
Protein Structure
UniProt Annotation
Function Involved in the recruitment of key centrosomal proteins to the centrosome. Provides centrosomal microtubule-nucleation activity on the gamma-tubulin ring complexes (gamma-TuRCs) and has critical roles in forming a focused bipolar spindle, which is needed for proper tension generation between sister chromatids. Required for localization of KIZ, AKAP9 and gamma-tubulin ring complexes (gamma-TuRCs). {ECO:0000269PubMed:19536135}.
Subcellular Localization Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:14654843, ECO:0000269PubMed:19536135}. Note=Localizes to the centrosome and centrosome-surrounding particles throughout the cell cycle. These particles disappear after microtubules are depolymerized using nocodazole, suggesting that CEP72-associating particles localize in a microtubule- dependent manner.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0007051 spindle organization
GO:0033566 gamma-tubulin complex localization
Cellular Component
GO:0005813 centrosome
GO:0005829 cytosol
Protein Structure and Domains
PDB ID
InterPro IPR003591 Leucine-rich repeat, typical subtype
IPR003603 U2A\'/phosphoprotein 32 family A, C-terminal
PFAM
PRINTS
PIRSF
SMART SM00369
SM00446
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9P209
PhosphoSite PhosphoSite-Q9P209
TrEMBL
UniProt Splice Variant
Entrez Gene 55722
UniGene Hs.591741
RefSeq NP_060610
HUGO HGNC:25547
OMIM
CCDS CCDS34126
HPRD 07685
IMGT
EMBL AB040952 AK001427 AK299072 BC000132 BC001750
GenPept AAH00132 AAH01750 BAA91685 BAA96043 BAG61138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca