InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HOXA5

Summary

InnateDB Protein

IDBP-10424.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HOXA5

Protein Name

homeobox A5

Synonyms

HOX1; HOX1.3; HOX1C;

Species

Homo sapiens

Ensembl Protein

ENSP00000222726

InnateDB Gene

IDBG-10422 (HOXA5)

Protein Structure

UniProt Annotation

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	13 [view]
Protein-DNA	2 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0001501	skeletal system development
GO:0002009	morphogenesis of an epithelium
GO:0003016	respiratory system process
GO:0006351	transcription, DNA-templated
GO:0007389	pattern specification process
GO:0007585	respiratory gaseous exchange
GO:0009952	anterior/posterior pattern specification
GO:0010870	positive regulation of receptor biosynthetic process
GO:0016477	cell migration
GO:0016525	negative regulation of angiogenesis
GO:0030324	lung development
GO:0030878	thyroid gland development
GO:0033599	regulation of mammary gland epithelial cell proliferation
GO:0035264	multicellular organism growth
GO:0043065	positive regulation of apoptotic process
GO:0045639	positive regulation of myeloid cell differentiation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048286	lung alveolus development
GO:0048704	embryonic skeletal system morphogenesis
GO:0048706	embryonic skeletal system development
GO:0060435	bronchiole development
GO:0060439	trachea morphogenesis
GO:0060441	epithelial tube branching involved in lung morphogenesis
GO:0060480	lung goblet cell differentiation
GO:0060481	lobar bronchus epithelium development
GO:0060484	lung-associated mesenchyme development
GO:0060535	trachea cartilage morphogenesis
GO:0060536	cartilage morphogenesis
GO:0060574	intestinal epithelial cell maturation
GO:0060638	mesenchymal-epithelial cell signaling
GO:0060644	mammary gland epithelial cell differentiation
GO:0060749	mammary gland alveolus development
GO:0060764	cell-cell signaling involved in mammary gland development