Version 5.4
Homo sapiens Protein: FCGR3B
Summary
InnateDB Protein IDBP-104307.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FCGR3B
Protein Name Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
Synonyms CD16; CD16b; FCG3; FCGR3; FCR-10; FCRIII; FCRIIIb;
Species Homo sapiens
Ensembl Protein ENSP00000294800
InnateDB Gene IDBG-104303 (FCGR3B)
Protein Structure
UniProt Annotation
Function Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.
Subcellular Localization Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.
Disease Associations
Tissue Specificity Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0019864 IgG binding
Biological Process
GO:0006955 immune response
Cellular Component
GO:0005886 plasma membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
PFAM
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75015
PhosphoSite PhosphoSite-O75015
TrEMBL E9PNY5
UniProt Splice Variant
Entrez Gene 2215
UniGene Hs.736230
RefSeq
HUGO HGNC:3620
OMIM 610665
CCDS CCDS41433
HPRD 09951
IMGT
EMBL AJ581669 AL451067 J04162 M24854 X07934 X16863 Z46223
GenPept AAA35881 AAA53507 CAA30758 CAA34753 CAA86296 CAE46408

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca