InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ATF6

Summary

InnateDB Protein

IDBP-104360.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATF6

Protein Name

activating transcription factor 6

Synonyms

ATF6A;

Species

Homo sapiens

Ensembl Protein

ENSP00000356919

InnateDB Gene

IDBG-104358 (ATF6)

Protein Structure

UniProt Annotation

Function

Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. {ECO:0000269PubMed:11158310}.

Subcellular Localization

Endoplasmic reticulum membrane; Single-pass type II membrane protein.Processed cyclic AMP-dependent transcription factor ATF-6 alpha: Nucleus. Note=Under ER stress the cleaved N- terminal cytoplasmic domain translocates into the nucleus. THBS4 promotes its nuclear shuttling.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	34 [view]
Protein-Protein	29 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003713	transcription coactivator activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006457	protein folding
GO:0006950	response to stress
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response
GO:0007165	signal transduction
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005789	endoplasmic reticulum membrane
GO:0016021	integral component of membrane