InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: NUF2

Summary

InnateDB Protein

IDBP-104446.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUF2

Protein Name

NUF2, NDC80 kinetochore complex component, homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000271452

InnateDB Gene

IDBG-104442 (NUF2)

Protein Structure

UniProt Annotation

Function

Acts as a component of the essential kinetochore- associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. {ECO:0000269PubMed:12438418, ECO:0000269PubMed:14654001, ECO:0000269PubMed:15062103, ECO:0000269PubMed:15235793, ECO:0000269PubMed:15239953, ECO:0000269PubMed:15548592, ECO:0000269PubMed:17535814}.

Subcellular Localization

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to kinetochores from late prophase to anaphase. Localizes specifically to the outer plate of the kinetochore. NDC80 is required for efficient kinetochore localization.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.

Experimentally validated
Total	32 [view]
Protein-Protein	30 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0007059	chromosome segregation
GO:0007067	mitotic nuclear division

Cellular Component

GO:0000775	chromosome, centromeric region
GO:0000777	condensed chromosome kinetochore
GO:0005634	nucleus
GO:0005829	cytosol
GO:0016020	membrane
GO:0031262	Ndc80 complex