InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LMX1A

Summary

InnateDB Protein

IDBP-104458.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LMX1A

Protein Name

LIM homeobox transcription factor 1, alpha

Synonyms

LMX1; LMX1.1;

Species

Homo sapiens

Ensembl Protein

ENSP00000294816

InnateDB Gene

IDBG-104454 (LMX1A)

Protein Structure

UniProt Annotation

Function

Acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter. Required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS and developing vertebrae (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in many tissues. Not found in heart, liver, spleen and testis. Relatively highly expressed in fetal brain. Isoform LMX1A-4B is expressed in testis. {ECO:0000269PubMed:12062816}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding